Kuznetsova Anna V.

Phone: (841)-2368467 (w)

E-mail: kuznetanna1@hotmail.com

Born. Penza, Nationality Russian

 Current Position

Associate Professor                 Start date: 09/2008 

Department of General and Clinical Pharmacology

Penza State University

 Personal Profile

Ph.D. in Biochemistry, Certificate in Pharmaceutical Chemistry, Interpreter Certificate 

Medicinal Chemistry, drug interaction, drug quality, Plant Chemistry, algae medicines. Vitamins.  Investigation of protein-protein interaction, ubiquitination and protein degradation pathway. Synthesis and application of new affinity sorbents for isolation of proteases. Protease activities, Chemistry education.

Education

2008. Department of Pharmaceutical Chemistry Moscow Medicinal Academy (I.M. Sechenov)

«Pharmaceutical Chemistry” (Certificate in Pharmaceutical Chemistry)

1998. PhD (Chemistry) Department of Natural Compounds, Chemistry department, Moscow State University, Russian Federation.

“Synthesis and application of new affinity sorbents for isolation of serine proteases”

 1994. MS (Chemistry). Department of Natural Compounds, Chemistry department, Moscow State University, Russian Federation. “Investigation of the proteases in urine of children with glomerulonephritis”

Work Experience

Institution & Location

2008 - present. Department of Pharmacology, Medical School, Penza State University- Penza, Russian Federation. Associate Professor

2004-2008. Department of Chemistry and Biochemistry, Penza State Pedagogic University- Penza, Russian Federation. Associate Professor

1998 - 2004. Department of Chemistry and Biochemistry, Penza State Pedagogic University- Penza, Russian Federation. Assistant Professor

2001-2002. Laboratory of Prof. Maria F. Czyzyk-Krzeska, Department of Molecular and Cellular Physiology, University of Cincinnati, USA. Post-Doctoral fellowship

1998. Laboratory of Prof. Baratova, A.N.Belozersky Institute of Physical and Chemical Biology, Moscow State University, Russian Federation. Research engineer

 1995-1998. Laboratory of Prof. V.M. Stepanov, Department of Natural Compounds, Chemistry Department, Moscow State University, Russian Federation. Ph.D. student

 Grants and Awards

1994-1998. The Russian Foundation for Basic Research 

Skills

Lectures: Pharmaceutical Chemistry, Organic Chemistry, Biotechnology, Russian and International approaches to the medical drugs standardization

Chromatography (different). Work with mammalian cells, IP, SDS-PAGE, Western blotting.

Synthesis of affine ligands for isolation of serine proteases.

Isolation of some proteases and their characterization, investigation of protease activity by chromogenic substrates.

Experience of work with various hardware and software (Windows, Internet Explorer, Origin, Excel, Microsoft Office PowerPoint, etc.).

List of Publications

Published in English originally

1. Induction of antioxidant activity by selenium compounds in the aspergillus niger mycelium Poluboyarinov P.A., Kuznetsova A.V., Moiseeva I.Ya., Mikulyak N.I., Kaplun A.P. Russian Journal of Bioorganic Chemistry. 2023. Т. 49. № 4. С. 823-835.

2.   Shpichka A.I., Semenova E.F., Kuznetsova A.V. About Riboflavin Definition in Biotechnological Raw Material. Modern Problems of Science and Education, N1. – 2011. P. 30-32

3.                  Petrushova O.P., Gengin M.T., Smetanin V.A., Kuznetsova A.V. Placental Enzymes Involved in Regulatory Peptide Metabolismin EPH-Gestosis. Biochemistry (Moscow) Supplement. Series B: Biomedical Chemistry. 2009. Т. 3.  № 3. С. 317-321

4.                  Anna V. Kuznetsova, Jaroslaw Meller, Phillip O. Schnell*, James A. Nash, Monika L. Ignacak, Yolanda Sanchez, Joan W. Conaway, Ronald C. Conaway, and Maria F. Czyzyk-Krzeska.  von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination. PNAS. March 4, 2003. V. 100. P 2706-2711.

5.                  Paulding WR, Schnell PO, Bauer AL, Striet JB, Nash JA, Kuznetsova AV, Czyzyk-Krzeska MF. Regulation of gene expression for neurotransmitters during adaptation to hypoxia in oxygen-sensitive neuroendocrine cells.  Microsc Res Tech. 2002 Nov 1;59(3):178-87. Review.